Research/ Awards >> Metabolic Bone Disease Unit

Endocrine department has Dual energy X-ray absorptiometry (DXA) scanning machine to measure bone mineral density (BMD). Two X-ray beams with different energy levels are passed through the patient. The BMD is estimated after subtracting absorption in the soft tissue (fat and muscle). Dual energy X-ray absorptiometry (DXA) is the most widely used to diagnose osteoporosis. BMD is expressed as T scores and Z scores. The T-score is the number of standard deviations by which a person's BMD differs from that of healthy young adults. The Z-score is the number of standard deviations by which a person's BMD differs from that of same age and sex. A T-score of -2.5 or less is indicative of osteoporosis. DXA scan is also used to measure total body composition.

Endocrine department runs Menopause clinic in association with OG department on every Tuesdays. This clinics addresses the clinical issues associated with post menopausal state. The department also runs following research projects in osteoporosis

International Multi-centre Trials:

  • A Phase III Randomized, Placebo –Controlled Clinical Trial to Assess the Safety and Efficacy of Odanacatib (MK-0822) to Reduce the Risk of Fracture in Osteoporotic Postmenopausal Women Treated With Vitamin D and Calcium – (5 year project) starting in 2009.
  • PEARL - PEARL (Postmenopausal Evaluation and Risk Reduction with Lasofoxifene) – 5 year project completed in January 2008.
  • QUINTILES – Generations study - “Effects of Arzoxifene on Vertebral Fracture Incidence and on Invasive Breast Cancer Incidence in Postmenopausal Women with Osteoporosis or with Low Bone Density” – 5 year project.
  • PEARL - PEARL (Postmenopausal Evaluation and Risk Reduction with Lasofoxifene) – 5 year project completed in January 2010.

Other projects:

  • Bone Mineral Density & Vitamin D status in patients who are on anti-convulsant therapy.
  • Bone Mineral Density and Vitamin D status in patients who are infected with HIV infection.
  • Bone Mineral Density, Calcium nutrition and Vitamin D status in patients who are admitted with acute hip fracture.
  • Prevalence of Osteoporosis and Vitamin D status in adult men in semi-urban Vellore.

Other cohorts in future to be studied:

  • Vitamin D status and Bone Mineral Density in patient who are affected with hemophilia.
  • Bone Mineral Density and Vitamin D status in patients who are affected with Thalesemia.
  • Vitamin D status and renal tubular disorders in subjects who are having with Wilson’s disease.
  • Fracture data collection over a period of 5 years in postmenopausal women who are from a semi-urban area in Vellore.

Interventional projects:

  • Vitamin D supplementation and fracture risk reduction and BMD assessment in postmenopausal women.
  • Vitamin D supplementation in pregnancy and assessment of maternal and fetal vitamin D status.